Adeno-associated Virus Production Service
Adeno-associated virus (AAV) is a type of parvovirus. Its genome is single-stranded DNA and has the ability to infect both dividing and non-dividing cells. Adenovirus or herpes virus is usually needed to help it replicate and expand in the body. Recombinant adeno-associated virus (recombinant AAV, rAAV) is a hybrid viral vector produced by combining the AAV2 type genome with the capsid protein genome of different serotypes. The CDS region sequence or RNAi interference sequence of the target gene can be inserted into the rAAV expression plasmid. After packaging the virus, the infected cell completes the operation of the target gene. In humans and mice, AAV infection can mediate the targeted integration of foreign genes with a low frequency (not higher than 2%). The viral genome forms a companion body in the infected cell without integration. Adeno-associated virus is widely used in the field of nerves, cardiovascular, liver, muscle, lung, and other fields, and its main application direction lies in localized injection and overall injection.
- CD BioSciences provides a variety of AAV vectors, which can manipulate coding and non-coding genes, such as lncRNA, microRNA, and circRNA, through overexpression, RNAi and other technologies.
- CD BioSciences provides more than 20 types of tissue-specific promoter AAV vectors, which can quickly achieve animal-level tissue-specific regulation and express foreign genes more efficiently and accurately.
- If you are not sure which serotype to choose, try the 9 with the broadest spectrum of infections.
The advantages of AAV compared to other viral vectors are as follows:
a. Long expression time: The vast majority of recombinant rAAVs will not integrate into the genome, but form episomes in tandem in the host cell and exist in the nucleus. The cells will lose episomes after cell replication and division, and therefore Loss of gene expression ability, rAAV can be expressed continuously for more than 6 months in tissues where cell division is not vigorous;
b. Strong diffusibility: rAAV has small size and high titer, so it has much higher diffusivity than adenovirus and lentivirus, can penetrate the blood-brain barrier, and is an ideal tool for neuron and glial cell infection;
Our Service Items
|Project name||Adeno-associated virus production service|
|Our Advantages||High efficiency of host cells infecting dividing or non-dividing cells.
Relatively high titers enable highly effective drug delivery.
|Product delivery mode||We will complete the project on time according to the agreed time, summarize the experimental data and conclusions, and complete the experimental report.|
Why choose us?
CD BioSciences provides corresponding adeno-associated virus production service. Adeno-associated virus production service is a personalized and customized innovative scientific research service. Before determining the corresponding analysis plan and price, each project needs to be evaluated. Our experienced and dedicated scientific researchers ensure that the most suitable methods and techniques are selected for each adeno-associated virus project. If you want to know more about service prices or technical details, please feel free to contact us.