Lentiviral Vector Optimization Service
Lentiviral vectors can effectively integrate exogenous genes or exogenous shRNA into the host chromosome, so as to achieve the effect of persistent expression of the target sequence. In terms of infection ability, it can effectively infect neuronal cells, liver cells, cardiomyocytes, tumor cells, endothelial cells, stem cells and other types of cells, so as to achieve good gene therapy effects. For some difficult-to-transfect cells, such as primary cells, stem cells, undifferentiated cells, etc., the use of lentiviral vectors can greatly improve the transduction efficiency of the target gene or target shRNA, and the target gene or target shRNA can be integrated into the host cell The probability of the genome is greatly increased, and the long-term and stable expression of the target gene or target shRNA can be achieved more conveniently and quickly. Therefore, in in vitro experiments and in vivo experiments, lentivirus has become one of the commonly used vector forms for expressing exogenous genes or exogenous shRNA, and is gaining more and more widespread applications.
Gene therapy based on lentiviral vectors has shown encouraging results in the treatment of a series of diseases. CD BioSciences now provides a large number of lentiviral vector optimization services, covering the entire lentiviral vector design, construction, and safety assessment process, including but not limited to:
- Optimization of lentiviral vector glycoprotein
- Ligand targeting lentiviral vector service
- miRNA-regulated lentiviral vector service
CD BioSciences provides pseudotyping services to expand natural tropism and improve the stable expression of lentiviral vectors in a variety of cells. So far, we have developed many vectors that target various cells, such as central nervous cells, and lentiviral vectors have been pseudotyped using glycoproteins of rabies virus.
Recently, our expert team has developed a weight targeting platform for designing new lentiviral vectors to improve the targeting specificity of multiple cell types. We have discovered a method for cell-specific targeting of lentiviral vectors through the use of receptor-ligand protein interactions.
CD BioSciences provides miRNA-based lentiviral vector optimization services. Our standardized protocol and strict quality control system enable us to provide the perfect solution for your project.
Our service items
|Project name||Lentiviral vector optimization service|
|Product delivery mode||We will complete the project on time according to the agreed time, summarize the experimental data and conclusions, and complete the experimental report.|
Why choose us?
CD BioSciences provides professional lentiviral vector optimization service, which can meet the needs of regular customers for hit identification on time and on budget. CD BioSciences relies on world-class viral vector technology expertise, we provide the highest quality one-stop Lentiviral vector optimization service for gene delivery, including the design and construction of lentiviral vectors according to different experimental needs. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project.