Herpes Simplex Virus (HSV) Vectors Service

Herpes simplex virus (herpes simplex virus, HSV) is a typical representative of herpes virus, named after vesicular dermatitis that occurs in the acute phase of infection, which can cause a variety of human diseases, such as gingivostomatitis, keratoconjunctivitis, encephalitis, reproductive system infections and neonatal infections. Recombinant herpes simplex virus (HSV) has recently become a promising viral vector in gene therapy and cancer treatment. It has a variety of applications, including delivery of genes to the nervous system, as an oncolytic agent, and for the development of anti-cancer, HSV and Other infectious diseases. HSV vectors have many advantages, such as natural neurotrophic properties, the ability to persist in a latent and free state throughout the life cycle of the host cell, and their large carrying capacity. These functions make them ideal viral vectors to meet a series of in vitro and in vivo gene delivery requirements.

Construction of vaccinia virus vector

CD BioSciences specializes in the design and construction of HSV vectors, which can be used to recombine live viruses, including wild-type and attenuated viruses, and replication-defective amplicons. We also provide packaging services for research grade and GMP grade HSV.

  • HSV-1 amplicon vectors in plasmid backbone

CD BioSciences provides HSV-1 amplicon plasmid, which contains the smallest viral sequence, namely the origin of replication (oriS) and packaging sequence (pac), and one or more target genes. The amplicon plasmid can be packaged into infectious but replication-defective virus particles with a helper function. This function can be provided in the form of a BAC carrying the entire HSV-1 genome, except for the virus packaging signal.

  • Virus packaging for HSV-1 and HSV-2 vectors

Our advantages

  • High insertion ability for a variety of foreign genes
  • Low cytotoxicity (ultracentrifugation purification process)
  • No mycoplasma contamination
  • No endotoxin, exogenous microorganisms, no acid host nucleus residue
  • Strong customer-centric after-sales service system

Our service items

Project name Herpes simplex virus (HSV) vectors service
Our service
  • HSV-1 amplicon vectors in plasmid backbone
  • Virus packaging for HSV-1 and HSV-2 vectors
Product delivery mode We will complete the project on time according to the agreed time, summarize the experimental data and conclusions, and complete the experimental report.
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Applications of HSV vectors

Recombinant HSV vectors can be used in a variety of gene therapy applications. The following are some of the main research areas where HSV vectors have been widely used:

  • HSV vectors as oncolytic agents
  • HSV vector vaccine
  • HSV vector as gene delivery vector

Why choose us?

CD BioSciences provides professional herpes simplex virus (HSV) vectors service, which can meet the needs of regular customers for hit identification on time and on budget. CD BioSciences relies on world-class viral vector technology expertise, we provide the highest quality one-stop herpes simplex virus (HSV) vectors service for gene delivery, including the design and construction of vaccinia vectors according to different experimental needs. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project.

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