Neutralizing Antibody Assays
Neutralizing antibody: The host's usual response to antigen or virus infection is to produce antibodies, which bind to the virus to inactivate (neutralize) it. Neutralizing antibodies can significantly reduce the efficacy of therapeutic drug proteins or peptides. Therefore, neutralizing antibody testing is a very critical part of immunogenicity testing. Generally, the U.S. Food and Drug Administration (FDA) believes that biological experiments can more truly reflect the environmental conditions in the body. For the detection of neutralizing antibodies, biological experiments should be related to the mechanism of action, otherwise the evaluation of the clinical effects of neutralizing antibodies through experiments will not provide sufficient information. Cell-level experiments are still recommended because they play a key role in understanding the importance of the patient's immune response to drug proteins. CD BioSciences can provide you with professional neutralizing antibody assays service to meet the specific needs of different customers.
For the cell-level neutralizing antibody detection experiment of a given sample, the following basic information needs to be provided:
▪ Stable cell line with stress response to drug products
▪ Measurable read data
▪ Strong signal-to-noise ratio in serum matrix
▪ Positive control antibody
▪ Medium to high production volume
▪ Adaptive automation
Due to the existence of the limiting factors (appropriate cell line, interference, specificity and sensitivity, etc.) to the cell level experiment, if it is found that the customer’s sample is not suitable for the neutralization cell level experiment, CD BioSciences can also provide the neutralization reaction capacity. Competitive ligand binding experiments or other optional experimental programs that have been validated strive to meet customer requirements and ultimately provide scientific and reliable experimental results.
Our service items
|Project name||Neutralizing antibody assays|
CD BioSciences offers neutralizing antibody assays service to meet the specific needs of different customers.
According to your scientific research needs.
- CD BioSciences will complete your project on time and efficiently. We have professional after-sales service: which has been established to provide customers with efficient, fast, practical and feasible solutions.
- CD BioSciences specializes in neutralizing antibody assays and we are committed to contributing to more customers.
- CD BioSciences cooperates with scientists from many pharmaceutical and biotechnology companies. We have a wealth of knowledge and experience to provide quality assurance services.
Why choose us?
CD BioSciences provides professional neutralizing antibody assays service to meet the needs of regular customers to determine hits on time and on budget. CD BioSciences relies on the world-class technical expertise, we provide customers with the best quality one-stop neutralizing antibody assays service, including the development of experimental procedures according to different experimental needs. Please feel free to contact us for more information, our scientists will tailor the most reasonable plan for your project.