Antibody Reformatting & Production

In addition to changing the Fc part of antibodies, the variable regions of immunoglobulins can also be reformatted into various fragments, such as Fab, F(ab)'2, scFv, VHH, and small antibodies, or can be combined to produce bispecific the second specificity of sex antibodies. Smaller antibody formats can be used to improve tumor/tissue permeability and relative ease of expression in non-mammalian systems. As a leader in antibody engineering, CD BioSciences can provide comprehensive antibody reformatting services.

Overall solution

▪ CD BioSciences can reformat antibody variable region genes (VH and VL) from a given antibody to encode different constant regions, including Fab.

▪ CD BioSciences can use a variety of species and isotypes, and can choose to synthesize constant regions. These expression constructs are transfected into HEK293 cells and then subjected to protein A purification or other selected affinity-based chromatography.

▪ Based on our comprehensive structure-based antibody reformatting service, new antibodies can be designed and engineered into scFv and VHH. CD BioSciences customize services according to customers' specific requirements. We also provide other epitope-specific antibody design services.

Our features

▪ Our antibody reformatting & production service can improve pharmacokinetics: isoelectric point engineering and engineering PH dependence.

▪ Our antibody reformatting & production service can improve drug properties: improve thermal stability, improve solubility, improve chemical stability and improve heterogeneity.

▪ Our antibody reformatting & production service can reduce immunogenicity.

Our advantages

▪ CD BioSciences' services are tailored to each project to ensure that goals are met or exceeded.

▪ CD BioSciences' experienced project team will be assigned to each study, focusing on completing the progress of the project in the shortest possible time.

▪ Our customers widely regard us as a professional and attentive partner that provides quality results.

Our Service Items

Project name Antibody reformatting & production
Our services

CD BioSciences offers antibody reformatting & production service to meet the specific needs of different customers.

Sample requirements

1. The order of VH and VL

2. DNA template (if DNA synthesis is not required)

3. The sequence of the complete IgG (if a specific constant region is required)

Deliverables

Plasmid DNA

Plasmid DNA for large-scale production

Purified IgG

Research report

Certificate of analysis

Timeline

4-5 weeks

Price Inquiry

Why choose us?

CD BioSciences provides professional antibody reformatting & productions to meet the needs of regular customers to determine hits on time and on budget. CD BioSciences relies on the world-class technical expertise, we provide customers with the best quality one-stop antibody reformatting & productions, including the development of experimental procedures according to different experimental needs. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project.

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