Replication-competent Adenovirus Assay

Adenoviruses with replication ability have been widely studied and used in anti-tumor gene therapy, but because of their replication ability, there are also some unsafe factors. More importantly, the replication-capable adenovirus increases with each successive amplification, so the risk of infection also increases. Therefore, sensitive assays for detecting replication-competent recombinant adenoviruses are necessary for characterizing adenovirus vectors.

Overall solution

We provide professional adenovirus detection methods with replication functions, including but not limited to:

  • Detection and analysis of cytopathic effect: CD BioSciences observes and analyzes the cytopathic effect of recombinant adenovirus vector infection and amplification.
  • CD BioSciences uses the combination of microcarrier cell culture and polymerase chain reaction (PCR) to quickly determine the replication-competent adenovirus: we incubate the adenovirus vector on A549 cells in the microcarrier cell culture system, and then specifically quantify it by E1 PCR detection of amplification increases the ability of adenovirus to replicate.
  • Other detection methods: CD BioSciences combines replication-competent adenovirus with immunocytochemical staining to assess the impact of cytopathic changes, and then differentially amplifies adenovirus vectors.

Our advantages

  • Mature cell technology platform: Many years of cellular experience
  • First-class expert technical team: The team is professional and experienced.
  • Our well-trained, friendly and professional research supervisors and project managers will complete your project on time through open communication channels and meet your requirements.
  • Professional after-sales service: A professional after-sales team is set up to provide customers with practical and feasible solutions efficiently and quickly.

Our service items

Project name Replication-competent adenovirus assay
Our services As a leading company in the field of viral vector construction, CD BioSciences provides a series of adenovirus detection services with replication capabilities.
Product delivery mode We will complete the project on time according to the agreed time, summarize the experimental data and conclusions, and complete the experimental report.
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Why choose us?

CD BioSciences provides professional replication-competent adenovirus assay to meet the needs of regular customers to identify hits on time and on budget. CD BioSciences relies on world-class cell engineering technology expertise, we provide customers with the best quality one-stop replication-competent adenovirus assay, including the development of experimental programs according to different experimental needs. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project.

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