Titration Service of AAV Vectors
Adeno-associated viruses are the simplest, non-enveloped, single-stranded DNA-deficient viruses found so far. They have the ability to infect dividing or non-dividing cells. Recombinant adeno-associated virus vector (rAAV) is derived from non-pathogenic wild-type adeno-associated virus. Due to its good safety, wide range of host cells (dividing and non-dividing cells), and low immunogenicity, it can express foreign genes in vivo. Long and other characteristics, these characteristics make recombinant AAV a very attractive tool vector for gene transfer and gene therapy. CD BioSciences offers titration service of AAV vectors to meet the specific needs of different customers. which can be used to express shRNA, human ORF and CRISPR in vivo and in vitro. We have an innovative AAV vector to ensure that every virus product you order has the advantages of stability, reliability, good repeatability, high purity, and high titer.
- CD BioSciences has established a series of analysis methods for in-depth analysis of AAV vector titers and candidate gene expression profiles, including rAAV genome copy number determination titration, infectious titration determination and genome titration determination.
- CD BioSciences is equipped with the most advanced technology, and we have successfully completed a number of AAV vector titration projects for global customers.
- CD BioSciences has detected the number of copies of the recombinant AAV vector genome in infected cells by using our new qPCR technology. Generally, a set of TaqMan PCR primers and probes will be designed to detect the AAV genome in the coding region.
The advantages of AAV compared to other viral vectors are as follows:
High safety: AAV has not been found to cause disease to humans, and it is the safest viral vector approved by the US FDA that can be directly used for human gene therapy;
Low immunogenicity: When AAV is used to infect muscle, brain, eye and other tissues with a local high dose, it is not easy to cause an immune response;
High stability: rAAV virus can be stored for 1 week at 4°C, and it is resistant to reagents such as chloroform.
Our service items
|Project name||Titration service of AAV vectors|
High efficiency of host cells infecting dividing or non-dividing cells.
Relatively high titers enable highly effective drug delivery.
|Product delivery mode||We will complete the project on time according to the agreed time, summarize the experimental data and conclusions, and complete the experimental report.|
Why choose us?
CD BioSciences provides corresponding titration service of AAV vectors. Titration service of AAV vectors is a personalized and customized innovative scientific research service. Before determining the corresponding analysis plan and price, each project needs to be evaluated. Our experienced and dedicated scientific researchers ensure that the most suitable methods and techniques are selected for each adeno-associated virus project. If you want to know more about service prices or technical details, please feel free to contact us.