Lentivirus Security Analysis Service

CD BioSciences provides a complete set of viral vector services, including vector engineering, preclinical process development, scale-up production and analysis development. Our goal is to extend gene therapy based on viral vectors to a wide range of clinical trials for the treatment of diseases. Taking into account the potential recombination risks of lentiviral vectors, the characteristics of integration into the mammalian cell genome, and the possibility of carcinogenesis by carrying foreign genes, although a large number of studies have also shown that no activation of proto-oncogenes is observed after infection with lentiviruses, but at the same time, an article reported that the proportion of partial clones detected in the treatment of thalassemia by lentiviral vectors in hematopoietic stem cells increased significantly, suggesting that the risk of gene mutations caused by random insertion still exists. CD BioSciences recommend that customers conduct a lentivirus safety analysis.

Overall solutions

In order to consider clinical applications, lentiviral vectors must meet the most stringent safety standards due to their viral nature.

  • CD BioSciences has established a set of evaluation methods to evaluate the safety of various lentiviral vectors, such as HIV-1-based lentiviral vector evaluation methods and non-human lentiviral vector evaluation methods.
  • In our HIV-1 platform, a replication-competent lentivirus (RCL) has been detected by using a positive control.
  • CD BioSciences can also evaluate the vector titer, the number of vectors, and the potential containment capacity of a variety of animal hosts.
  • At present, we have successfully developed many detection systems for customers to evaluate the pharmacodynamics and biological safety of lentiviral vectors.

Our service items

Project name Lentivirus security analysis service
Our advantages
  • Low cytotoxicity (ultracentrifugation purification process)
  • No mycoplasma contamination
  • No endotoxin, exogenous microorganisms, no acid host nucleus residue
  • Strong customer-centric after-sales service system
Product delivery mode We will complete the project on time according to the agreed time, summarize the experimental data and conclusions, and complete the experimental report.
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Why choose us?

CD BioSciences provides professional lentivirus security analysis service, which can meet the needs of regular customers for hit identification on time and on budget. CD BioSciences relies on world-class viral vector technology expertise, we provide the highest quality one-stop lentivirus security analysis service for gene delivery, including the design and construction of lentivirus vectors according to different experimental needs. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project.

Notice

It is recommended that you strictly refer to the following standard operations when using lentivirus for experiments:

A. Please wear laboratory clothes, gloves, masks and hats when operating the virus.

B. It is recommended to use a biological safety cabinet during virus operation! Be especially careful not to generate aerosols or splashes when handling viruses. If the biological safety cabinet is contaminated with viruses during operation, please wipe it clean with 70% alcohol or 0.06% NaClO3 solution immediately.

C. Special waste treatment: 6% NaClO3 solution soaked for 30 minutes, or sealed and autoclaved, then thrown into a biological waste collection bag.

D. If you accidentally touch the skin, please wash immediately with plenty of soap and water; after the experiment, wash your hands with soap and water.

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