Endocytosis and Internalization Potency Detection
An important mechanism of action of therapeutic antibodies is to induce the internalization and turnover of cell surface receptors, leading to receptor down-regulation and antibody endocytosis. This receptor-mediated internalization has shown great potential in various therapeutic or diagnostic applications. Therefore, one of the prerequisites for antibodies designed for antibody-drug conjugates (ADC) is to induce rapid receptor internalization, thereby ensuring cell-specific drug delivery. After internalization, the antibody-receptor complex can circulate back to the plasma membrane or be degraded by late endosomes and lysosomes. CD BioSciences can provide you with professional endocytosis and internalization potency detection service to meet the specific needs of different customers.
- CD BioSciences currently offers this unique opportunity for our worldwide clients to obtain high-quality service of detecting endocytosis and internalization potencies for lead antibody candidates.
- CD BioSciences can monitor various processes of cellular uptake and internalization by acidifying the particles or protein conjugates taken up by cells. Particles and proteins enter vesicles through internalization, and these vesicles are acidic relative to the extracellular environment. The use of pH-sensitive fluorescent probes can detect pathway progress and track the entire process from early endosome (pH 6.3) to lysosome (pH 4.7) or recycling.
- When a cell surface receptor binds to its specific antibody, receptor-mediated endocytosis can be induced. They are often used as a vehicle for targeted delivery of therapeutic drugs, toxins, enzymes, or DNA. CD BioSciences uses a variety of antibody-labeled stains to detect anti-internalization.
Our service items
|Project name||Endocytosis and internalization potency detection|
CD BioSciences offers endocytosis and internalization potency detection service to meet the specific needs of different customers.
According to your scientific research needs.
- CD BioSciences specializes in endocytosis and internalization potency detection service and we are committed to contributing to more customers.
- CD BioSciences cooperates with scientists from many pharmaceutical and biotechnology companies. We have a wealth of knowledge and experience to provide quality assurance services.
- CD BioSciences will complete your project on time and efficiently. We have professional after-sales service: which has been established to provide customers with efficient, fast, practical and feasible solutions.
- We have established a professional after-sales service team to provide customers with efficient, fast and practical solutions.
Why choose us?
CD BioSciences provides professional endocytosis and internalization potency detection service to meet the needs of regular customers to determine hits on time and on budget. CD BioSciences relies on the world-class technical expertise, we provide customers with the best quality one-stop endocytosis and internalization potency detection service, including the development of experimental procedures according to different experimental needs. Please feel free to contact us for more information, our scientists will tailor the most reasonable plan for your project.