Protein-Ligand Binding Affinity Determinations

Modern drug discovery is usually based on finding new small molecule inhibitors that can bind disease-related proteins and inhibit their biological activity and interactions. Therefore, understanding how small molecule inhibitors bind to their target proteins is one of the main focuses of biochemical and medical research. Understanding the strength of this interaction is an important step in any drug discovery plan, because it can be based on the binding affinity of the inhibitor. Inhibitors are ranked. Quantifying the strength of protein-ligand interactions is crucial in drug development. CD BioSciences provides professional protein-ligand binding affinity determinations services to meet the specific needs of different customers. If you have any needs in this regard, please feel free to contact us.

Overall solution

CD BioSciences provides nuclear magnetic resonance (NMR) spectroscopy, which is a mature method for screening protein ligands and quantifying protein-ligand binding.

CD BioSciences measures the binding constant by tracking the peak intensity change or chemical shift perturbation of the labeled amino acid resonance in the ligand titration experiment.

CD BioSciences can use molecular dynamics simulation methods to determine the binding affinity of small molecules and proteins, and can use binding energy decomposition to determine which amino acids contribute to the binding process.

Our service items

Project name Protein-ligand binding affinity determinations
Our services

CD BioSciences offers protein-ligand binding affinity determinations service to meet the specific needs of different customers.

Material Required

According to your scientific research needs.

Deliverables

Study report

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Our advantages

▪ The core R&D team of CD BioSciences has a multidisciplinary background, including medicine, pharmacy, biology, materials science and other R&D backgrounds. They have active innovative thinking, rich biological expertise and experimental research experience.

▪ CD BioSciences specializes in protein-ligand binding affinity determinations service and we are committed to contributing to more customers.

▪ Our team has extensive knowledge and experience, working with scientists, bio-professionals and project managers from more than 100 pharmaceutical and biotech companies and organizations around the world.

▪ CD BioSciences will complete your project on time and efficiently. We have professional after-sales service: which has been established to provide customers with efficient, fast, practical and feasible solutions.

Why choose us?

CD BioSciences provides professional protein-ligand binding affinity determinations service to meet the needs of regular customers to determine hits on time and on budget. CD BioSciences relies on the world-class technical expertise, we provide customers with the best quality one-stop protein-ligand binding affinity determinations service, including the development of experimental procedures according to different experimental needs. Please feel free to contact us for more information, our scientists will tailor the most reasonable plan for your project.

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