Lentiviral Vector Development Service
A number of studies have shown that lentiviral vectors have the advantages of infecting non-dividing cells, long-term expression, low host cell immune response, and low cytotoxicity. Due to its own structural characteristics, it can package 8~10kb, which is suitable for multi-gene expression systems, and the genome contains fewer nucleotides, has a strong resistance to gene silencing, and is more expressive in the host, and the entire transcription area is integrated during integration. It can be integrated, which reduces the chance of activation of the promoter by the lentivirus. CD BioSciences offers lentiviral vector development service to meet the specific needs of different customers.
CD BioSciences is an industry leader in LV development. We have a unique LVs development platform and advanced technology that enable us to support each customer's project engineering by optimizing and modifying lentivirus. The LV development services we provide mainly include the following:
- Gene silencing
- Stem cell research
- Cellular reprogramming
RNAi-mediated gene silencing has become an indispensable technology for studying gene function. CD BioSciences can engineer LVs to achieve stable and effective gene silencing in various cells. At present, gene-silencing LVs have been successfully used in some basic research and clinical applications.
A large number of studies have shown that the delivery of genes of interest to these stem cells through LV can be used in a variety of basic research, such as basic biology, drug discovery, transplantation and regenerative medicine. In order to obtain effective and stable transgene expression in stem cells, CD BioSciences can make various modifications to LV, such as using appropriate promoters, adding regulatory elements, etc.
Currently, by introducing multiple reprogramming factors RF into single cells (such as fibroblasts, keratinocytes, and hematopoietic stem cells), multiple LVs have been successfully used for reprogramming of various cell types.
LV plays an immunomodulatory role by effectively transducing immune cells (such as dendritic cells (DC)). DCs are specialized antigen-presenting cells in the immune system that regulate immunity and tolerance. LV targeting DC has been used as a lentiviral vaccine against tumors and infectious diseases.
Our service items
|Project name||Lentiviral vector development service|
|Product delivery mode||We will complete the project on time according to the agreed time, summarize the experimental data and conclusions, and complete the experimental report.|
Why choose us?
CD BioSciences provides professional lentiviral vector development service, which can meet the needs of regular customers for hit identification on time and on budget. CD BioSciences relies on world-class viral vector technology expertise, we provide the highest quality one-stop lentiviral vector development service for gene delivery, including the design and construction of lentivirus vectors according to different experimental needs. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project.